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. Author manuscript; available in PMC: 2023 Jun 17.
Published in final edited form as: ACS Chem Biol. 2022 May 25;17(6):1472–1484. doi: 10.1021/acschembio.2c00051

Figure 5.

Figure 5.

Structural comparison of Fes-SH2 and its variants. (a) Superposition of Fes-SH2 and its variants. The following bound structures are depicted: Feswt (green, PDB ID: 3BKB), sFes1 (magenta), and sFesS (blue). Structures were aligned based on Cα co-ordinates using the ALIGN function in PyMol. (b) pTyr-binding pocket of Feswt (bound). Hydrogen bonds are shown as dashed lines and numbers refer to interactions described in the main text. (c) pTyr-binding pocket of sFes1 (bound). Hydrogen bonds are shown as dashed lines and numbers refer to interactions described in the main text. (d) pTyr-binding pocket of sFesS (bound). Hydrogen bonds are shown as dashed lines and numbers refer to interactions described in the main text.