Scheme 4. Synthesis of Bis-hetero-aminooxy-modified 2′-OMe-uridine Building Blocks.
For 19, R1 is hexadecyl; for 20, 22, and 24, R1 is hexadecyl, and R2 is protected folate; and for 21, 23, and 25, R1 is hexadecyl, and R2 is lipoate.
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