. 2022 Jun 17;24(25):4496–4501. doi: 10.1021/acs.orglett.2c00988

Table 1. Sequences, mRNA Targets, Chemistry, and Ligand Features of siRNA Sense Strand Oligonucleotides (ON) with AOCC Building Blocks at the 5′ End^a.

Uppercase italicized and lowercase letters represent 2′-F and 2′-OMe nucleosides, respectively. Phosphorothioate (PS) linkages are indicated by the “•” symbol. AOCC-derived conjugates in the context of 2′-OMe-uridine are I to VI for ON1–ON6, respectively, and are shown in Figure 2.

Table 1. Sequences, mRNA Targets, Chemistry, and Ligand Features of siRNA Sense Strand Oligonucleotides (ON) with AOCC Building Blocks at the 5′ Enda.

Table 1. Sequences, mRNA Targets, Chemistry, and Ligand Features of siRNA Sense Strand Oligonucleotides (ON) with AOCC Building Blocks at the 5′ End^a.