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. 2022 Feb 3;16(13):2537–2557. doi: 10.1002/1878-0261.13183

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© 2022 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 6 — Copy‐number increase and upregulation of TLK1 and MK5 in metastatic PCa. Bioinformatic analysis of PCa data sets to determine: (A) genomic alteration of MK5; (B) mRNA expression of TLK1 based on nodal metastasis; (C) mRNA expression of MK5 based on nodal metastasis; (D) mRNA expression of TLK1 based on tumour Gleason score; (E) mRNA expression of MK5 based on tumour Gleason score. CRPC= castration‐resistant prostate cancer, PRAD = prostate adenocarcinoma, NEPC = neuroendocrine prostate cancer. Box‐and‐whisker plots represent interquartile range (IQR) including minimum, 25th percentile, median, 75th percentile and maximum values. N0 = no regional lymph node metastasis and N1 = metastases in 1 to 3 axillary lymph nodes. GS = Gleason score. *=P < 0.05, **=P < 0.005 and ****=P < 0.0001.