Table 1.

Concomitant medications within spontaneous reports of myocarditis and pericarditis submitted to EudraVigilance for the European Union and European Economic Area only, following COVID-19 mRNA vaccines

	Tacrolimus	Mycophenolate mofetil	Methotrexate	Ciclosporin	Prednisolone	HIV treatments	Cancer treatments*	Total†
Comirnaty
Myocarditis	1	2	5	0	6	1	14	29
Pericarditis	0	2	7	1	8	1	25	44
Myopericarditis	0	0	0	0	0	0	2	2
Spikevax
Myocarditis	1	2	1	0	0	0	0	4
Pericarditis	0	0	1	0	1	0	1	3
Myopericarditis	0	0	0	0	0	0	0	0
Total*†	2	6	14	1	15	2	42	82

Reports of myocarditis or pericarditis were searched in the EudraVigilance database following COVID-19 mRNA vaccines, either COVID-19 Vaccine Moderna (Spikevax) or Pfizer/BioNTech (Comirnaty). Medications were used as a proxy for immunocompromised subgroups: transplant recipients (tacrolimus, mycophenolate mofetil, methotrexate, prednisolone, ciclosporin and steroids (including prednisolone)), HIV infection and patients undergoing cancer treatment.

Numbers in bold font represent totals.

*Hydrocortisone excluded as no indications given within reports and the drug is commonly used to treat other conditions.

†Reports may contain more than one concomitant medication and/or more than one event.

mRNA, messenger RNA.