Table 1.
Patients’ characteristics of the study sample
| Characteristic | Development Set (n = 141) | Validation Set (n = 77) | P Value |
|---|---|---|---|
| Age (years)a | 63.43 ± 9.25 | 64.49 ± 10.40 | 0.277# |
| Gender | 0.226 | ||
|
Male Female |
87(61.70) 54(38.30) |
41(53.25) 36(46.75) |
|
| Tumor location | 0.200 | ||
| Head | 88(62.41) | 40(51.95) | |
| Body | 19(13.48) | 17(22.08) | |
| Tail | 34(24.11) | 20(25.97) | |
| Laboratory results* | |||
| Cancer antigen 19–9(U/ml) | 141.2(0.6–7767) | 92.1(2–10,000) | 0.573 |
| Bilirubin (μmol/L) | 13.8(3.7–436.1) | 13.2(3.8–450.4) | 0.334 |
| Neutrophils/Lymphocytes | 2.49 (0.52–13.25) | 2.41(0.91–4.99) | 0.479 |
| Platelets/Lymphocytes ratio | 134.12(61.07–463.33) | 137.06(2.4–428) | 0.985 |
| C-reactive protein(mg/L) | 1.2(0.3–32.9) | 1.6(0.3–381.2) | 0.294 |
| Adjuvant therapy performedΣ | 106(75.18) | 59(76.62) | 0.812 |
| Type of pancreatic surgery£ | 0.924 | ||
| Standard pancreaticoduodenectomy | 54 (38.30) | 29 (37.66) | |
| Standard distal pancreatectomy | 52 (36.88) | 28 (36.36) | |
| Extended pancreaticoduodenectomy | 26 (18.44) | 14 (18.18) | |
| Extended distal pancreatectomy | 8 (5.67) | 6(7.79) | |
| Standard total pancreatectomy | 1 (0.71) | 0(0.00) | |
| Negative resection margin (R0) | 140(99.29) | 76() | 0.663 |
| Primary tumor (T) stage | 0.900 | ||
| T1 | 44 (31.21) | 22(28.57) | |
| T2 | 79 (56.03) | 44(57.14) | |
| T3 | 18(12.76) | 11(14.29) | |
| Regional lymph node (N) stage | 0.064 | ||
| N0 | 80 (56.74) | 54(70.13) | |
| N1 | 53 (37.59) | 17(22.08) | |
| N2 | 8 (5.67) | 6(7.79) | |
| AJCC prognostic stage group | 0.090 | ||
| IA | 29(20.57) | 12(15.58) | |
| IB | 41(29.08) | 32(41.56) | |
| IIA | 10(7.09) | 8(10.39) | |
| IIB | 51(36.17) | 17(22.08) | |
| III | 9(6.38) | 5(6.49) | |
| IV | 1(0.71) | 3(3.90) | |
| Tumor differentiation | 0.108 | ||
| Well differentiated | 0(0.00) | 0(0.00) | |
| Moderately differentiated | 70(49.65) | 47(61.04) | |
| Poorly or undifferentiated | 71(50.35) | 30(38.96) | |
| Lymphovascular or microvascular invasion present | 27(19.15) | 18(23.38) | 0.461 |
Data are numbers, with percentages in parentheses, unless otherwise specified
aData are means ± standard deviations
*Data are medians, with ranges in parentheses
Σ53 patients didn’t receive adjuvant therapy because of underlying diseases and perioperative complications
£Type of surgery was classified as standard surgery or extended surgery involving concomitant vein or additional organ resection
#Fisher’s exact test, χ2 test or one-way analysis of variance were used to compared data, excepted where indicated