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. 2022 Jul 4;19:173. doi: 10.1186/s12974-022-02532-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Repopulation of microglia does not ameliorate Aβ pathology and neuritic damage in APP/PS1 male mice. Experimental paradigm depicting duration of PLX5622 treatment and subsequent microglial repopulation (A). Representative immunofluorescent 20× images of the subiculum in control versus PLX-repopulated group, showing Aβ plaque (6E10, red), microglia (Iba1, magenta), and neuritic damage (LAMP1, green) (B). Scale bar represents 200 µm. There was no difference in the total area (C), size (D) and number (E) of plaques between the control and PLX-repopulated groups in Subiculum or CA1. Ratio of plaque-associated LAMP1⁺ neuritic damage to plaque load was similar between control and PLX-repopulated group (F). Student’s t-test. Data are presented as mean ± SEM (n = 6)