Fig. 20. (A) In vivo assay performed by Vallet-Regí's Group. (B–H) In vivo evaluation of different gene expressions (measured by qPCR) in femur bone of healthy controls and ovariectomized (OVX) mice in the presence of SOST-siRNA and osteostatin loaded in MSNs-PA@PEI (OST-siRNA). A gold standard treatment control has been used (free PTH 100 μg kg−1 every 2 days) (PTH), and free MSNs-PA@PEI nanoparticles were used as negative control (MSNs). *p < 0.05 vs. control; #p < 0.05 vs. OVX; $p < 0.01 vs. OVX.615 Reproduced with permission from ref. 615. Copyright 2021, Wiley-VCH Gmb.
