Fig. 34. Schematic depiction of the mechanism of action of reactive oxygen species (ROS)-responsive MSN-based antimicrobial nanosystems. MSNs were loaded with vancomycin (VAN) and functionalized with a ROS-degradable thioketal grafted methoxy poly(ethylene glycol) (mPEG-TK) capping shell. The presence of ROS in the bacterial microenvironment produces the cleavage of TK linker and polymer degradation. This leads to pore uncapping, VAN release and eventually bacterial death.771 Adapted with permission from ref. 771. Copyright 2020. Elsevier Ltd.
