Fig. 35. Schematic illustration of the temperature-responsive release behaviour of nanosystems consisting of Fe3O4 cores and large-pore mesoporous silica shells, which were loaded with lysozyme (LYS) and capped with the thermo-responsive polymer poly(N-isopropylacrylamide) (PNIPAM). At 25 °C PNIPAM is in extended conformation, closing the mesopores and impeding LYS release. When the temperature increases to 37 °C, PNIPAM adopts a globular conformation that produces pore opening and allows LYS release.773 Adapted with permission from ref. 773. Copyright 2015, Elsevier Ltd.
