Examples of different types of silica-based nanocarriers (MSNs) applied in bone diseases.

Carrier type(s)	Drug(s)	Cell line(s)	In vivo model	Application	Ref.
MSNs	Dexamethasone	BMSCs	Bone targeting	Bone tissue regeneration	616
			Mice	Osteoporosis
MSNs	BMP-2	MSCs	None	Bone tissue regeneration	617
	pDNA
MSNs	BFP-BMP-7	MG-63	None	Bone tissue engineering	618
		hMSCs
MSNs	BMP-2	BMSCs	Ectopic bone formation	Bone tissue engineering	619
	Dexamethasone		Rats
MSNs	QK peptide	HUVEC	Critical-sized calvarial defect	Bone tissue engineering	620
	Dexamethasone	BMSCs	Rats
MSNs	Enoxacin	S. aureus	Infection model	Bone tissue engineering and infection	621
		BMMs	Rats
MSNs	miR-26a	BMSCs	None	Bone tissue regeneration	622
MSNs	(rno)-miRNA-26a-5p	BMSCs	None	Bone tissue engineering	623
MSNs	Cu2+	Macrophages	None	Bone tissue engineering	624
		BMSCs
MSN-G3	Levofloxacin	MC3T3-E1	None	Bone tissue engineering and infection	625
	Zn2+	E. coli
MSNs	Ag+	BMSCs	None	Bone tissue engineering and infection	626
	PDGF-BB	E. coli
		S. aureus
		P. aeruginosa
		C. sporogenes
		B. fragilis
MSNs	Lactoferrin	ADSCs	None	Bone tissue regeneration	627
				Osteoporosis
Ce@MSNs		MC3T3-E1	None	Osteoporosis	627
		RAW264.7
MSNs	Licorice-ISL	BMMs	Calvarial bone erosion	Osteoporosis	628
			Mice
MSNs	17β-E2	MC3T3-E1	OVX	Osteoporosis	629
			Mice
MSNs (TDNs)	MCP-1	BMMSCs	OVX	Osteoporosis	630
			Mice
MSNs	SOST SiRNA	MEFs	OVX	Osteoporosis	615 and 631
	Osteostatin		Mice
MSNs	DOX	MG-63	None	Osteosarcoma	632
Fe-MSNs magnetic responsive	PLK1 siRNA	KHOS	None	Osteosarcoma	633
MNC-MSNs pH-responsive	PLK1 SiRNA	KHOS	None	Osteosarcoma	634
MSNs ultrasound responsive	DOX	HOS	None	Osteosarcoma	635
MSNs pH-responsive	DOX	HOS	None	Osteosarcoma	291
MSNs pH Responsive	BMP-2	BMSCs	Ectopic bone formation	Bone tissue regeneration	636
	Dexamethasone		Mice
MSN enzyme responsive	Ag+	S. aureus	Femur defect	Bone tissue regeneration and infection	637
			Rats
MSN-PEM/Ti	17β-E2	OBs	None	Bone tissue engineering	638
MSN/nanofibrous scaffold	BMP-2	C2C12	None	Bone tissue engineering	639
	Deferoxamine	hMSCs
MSN/GelMA hydrogel	Metformin	SHEDs	None	Bone tissue regeneration	640
MSN/HA	Zoledronic acid	L-929	None	Bone tissue regeneration	641
		BMMs
MSN/PLLA/PCL scaffolds	Dexamethasone	BMSCs	Calvarial bone defect	Bone tissue regeneration	642
			Rats
nHA/MSNs	Dexamethasone	MC3T3-E1	Calvarial bone defect	Bone tissue engineering	643
			Rats
MSN/PLGA-PNIPAM hydrogel	miRNA-222	BMSCs	Mandibular defect	Bone tissue engineering	644
	Aspirin		Rats
MSN/PCL nanofiber scaffold	COL1A1 SiRNA	HDFs	Subcutaneous implantation	Bone tissue regeneration	645
			Rats