Bacterial biofilm-targeted MSNs as antimicrobial delivery systems.
| Targeting liganda | Bacterial biofilmc | Drug loaded | Nanocarrierb | Assay | Ref. |
|---|---|---|---|---|---|
| DAMO | S. aureus | Levofloxacin | MCM-41 DAMO-MSNs | In vitro | 727 and 739 |
| G3 | E. coli | Levofloxacin | MCM-41 G3-MSNs | In vitro | 727 |
| G3 | E. coli | Levofloxacin | MCM-41 Mn+-G3-MSNs | In vitro | 625 |
| ConA | E. coli | Levofloxacin | MCM-41 ConA-MSNs | In vitro | 740 |
| Arabic gum | E. coli | Moxifloxacin | MCM-41 AG-CO@MSNs | In vitro & in vivo | 741 |
a
DAMO: N-(2-aminoethyl)-3-aminopropyltrimethoxy-silane; G3: poly(propyleneimine) third-generation dendrimer; and ConA: concanavalin A.
b
MCM-41 DAMO-MSNs: MCM-41 type MSNs functionalized with DAMO; MCM-41 G3-MSNs: MCM-41 type MSNs functionalized with G3; MCM-41 Mn+-G3-MSNs: MCM-41 type MSNs functionalized with G3 coordinated to Mn+ (Mn+ = Zn2+, Ag+); MSNs-ConA: MCM-41 type MSNs decorated with ConA; and AG-CO@MSNs: MSNs coated with Arabic gum containing colistin.
c
E. coli: Escherichia coli; and S. aureus: Staphylococcus aureus.