Table 2.
INR | ALT | AST | ALP | TBili | Creat | Adducts | |
---|---|---|---|---|---|---|---|
All (N = 303) | 2.5 (1.2–27.1) | 884 (22–13 100) | 823 (42–21 020) | 148 (36–952) | 20.4 (0.4–63.3) | 1.4 (0.1–10.8) | 0.003 (0.0–23.122) |
IND → APAP | |||||||
All (n = 45) | 2.3 (1.3–9.3) | 3704 (645–13 100) | 3120 (238–21 020) | 123 (42–507) | 4 (0.4–21.9) | 2.7 (0.28–7.74) | 3.751 (0.248–23.12) |
Def/HL (n = 40) | 2.55 (1.4–9.3) | 3975 (645–13 100) | 3782 (373–21 020) | 133 (42–507) | 4.15 (0.8–21.9) | 2.8 (0.28–7.74) | 4.049 (0.248–23.12) |
Probable (n = 5) | 1.8 (1.3–2.1) | 1322 (7.9–3971) | 884 (238–2077) | 96 (61–133) | 3.9 (0.4–10.3) | 1.4 (0.4–7.6) | 0.869 |
IND → AIH | |||||||
All (n = 34) | 2.7 (1.2–24.8) | 607 (29–2671) | 706 (42–2182) | 155 (62–431) | 24.2 (6.8–48.4) | 1.15 (0.5–10.75) | 0 (0–0.252) |
Def/HL (n = 11) | 3.409 (1.6–12.3) | 659 (84–2064) | 707.09 (189–1829) | 183 (84–431) | 27.0 (18.9–43.5) | 2.47 (0.6–7.3) | 0.011 (0–0.063) |
Probable (n = 23) | 2.7 (1.2–24.8) | 756 (29–2671) | 720 (42–2182) | 156 (62–290) | 23.2 (6.8–48.4) | 1.2 (0.5–10.75) | 0 (0–0.252) |
IND → DILI | |||||||
All (n = 24) | 2.5 (1.5–13.5) | 760 (87–4874) | 687 (76–3632) | 163 (60–449) | 26.2 (5.7–53.0) | 1.15 (0.9–3.9) | 0 (0–0.208) |
Def/HL (n = 8) | 2.45 (1.5–5.3) | 826 (87–4874) | 668 (251–3632) | 161 (107–255) | 26.95 (5.7–41.5) | 0.995 (0.7–3.1) | 0.0345 (0–0.082) |
Probable (n = 16) | 2.5 (1.5–13.5) | 759 (161–2117) | 734.5 (76–1694) | 163 (60–449) | 24.75 (9.8–53.0) | 1.55 (0.3–3.9) | 0 (0–0.208) |
IND → shock | |||||||
All (n = 12) | 2.9 (1.6–7.6) | 2858 (107–8230) | 4184 (84–19 614) | 128 (44–201) | 3.05 (1.1–15.0) | 2.63 (0.69–9.50) | 0.016 (0–0.737) |
Def/HL (n = 5) | 2.8 (1.6–4.2) | 1083 (107–3356) | 1310 (84–5498) | 148 (57–193) | 3.7 (1.3–15.0) | 2.66 (1.8–9.5) | 0.379 (0.007–0.737) |
Probable (n = 7) | 3.0 (1.9–7.6) | 3878 (1017–8230) | 7989 (539–19 614) | 85 (44–201) | 2.3 (1.1–8.0) | 2.6 (0.69–6.3) | 0.0115 (0–0.1) |
All other (n = 14) | 2.2 (1.3–6.5) | 372 (33–6604) | 420 (108–15 725) | 151 (74–468) | 28.0 (9.2–48.4) | 1.57 (0.1–2.88) | 0.015 (0–0.221) |
Viruses (n = 13) | 2.7 (1.62–81) | 2002 (445–7320) | 1326 (371–16 000) | 156 (108–554) | 21.4 (2.6–34.3) | 1.5 (0.6–4.8) | 0.002 (0–1.361) |
IND | |||||||
All (n = 150) | 2.8 (1.1–18) | 746.5 (27–10 153) | 627 (51–8795) | 159 (47–952) | 21.75 (1.3–63.3) | 1.3 (0.39–10.1) | 0 (0–1.364) |
True (n = 90) | 2.9 (1.3–18) | 737.5 (27–10 153) | 646.5 (51–8052) | 161.5 (47–952) | 22.25 (1.5–51.5) | 1.45 (0.4–10.1) | 0 (0–1.364) |
Indeterminable (n = 60) | 2.6 (1.1–9.5) | 761.5 (456–6624) | 610 (100–8795) | 159 (55–401) | 21.45 (1.3–63.3) | 1.2 (0.39–5.1) | 0 (0–0.826) |
AIH autoimmune hepatitis, APAP acetaminophen, DILI drug-induced liver injury
→, IND the diagnosis was changed to APAP or autoimmune