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. 2022 May 10;221(3):iyac075. doi: 10.1093/genetics/iyac075

Fig. 6.

Fig. 6.

Core RNA splicing regulator genes are required for the longevity and stress resistance of the ifg-1 mutant. Lifespan and cadmium resistance of wild type (WT) and ifg-1(cxTi9279) mutant worms after a) sma-2 (RNAi), b) sma-3 (RNAi), c) snr-1 (RNAi), d) snr-2 (RNAi), and e) uaf-2 (RNAi) knockdown. P-values are shown comparing the treatment RNAi with EV control in colored fonts that correspond to either the WT or the ifg-1(cxTi9279) mutant. Three independent trials were performed for each assay; detailed statistics for individual trials are shown in Supplementary Tables 6–8. Trial 1 is shown for longevity assay, and trial 2 is shown for cadmium survival. f) Model of proposed regulation between ifg-1- and sma-2-dependent RNA-splicing factors in the longevity and stress resistance phenotype of the ifg-1 mutant.