Table 3.

Univariate Log Rank and Multivariate Analyses for Disease-Specific and Metastasis-Free Survival in Upper Urinary Tract Urothelial Carcinoma

Parameter	Category	Case No.	Disease-Specific Survival					Metastasis-Free Survival
			Univariate Analysis		Multivariate Analysis			Univariate Analysis		Multivariate Analysis
			No. of Events	P-value	RR	95% CI	p-value	No. of Events	p-value	RR	95% CI	P-value
Gender	Male	158	28	0.8286	–	–	–	32	0.7904	–	–	–
	Female	182	33		–	–	–	38		–	–	–
Age (years)	<65	138	26	0.9943	–	–	–	30	0.8470	–	–	–
	≥65	202	35		–	–	–	40		–	–	–
Tumor side	Right	177	34	0.7366	–	–	–	38	0.3074	–	–	–
	Left	154	26		–	–	–	32		–	–	–
	Bilateral	9	1		–	–	–	0		–	–	–
Tumor location	Renal pelvis	141	24	0.0079*	1	–	0.613	31	0.0659	–	–	–
	Ureter	150	22		0.638	0.175–2.327		25		–	–	–
	Renal pelvis and ureter	49	15		0.519	0.130–2.066		14		–	–	–
Multifocality	Single	273	48	0.0026*	1	–	0.405	52	0.0127*	1	–	0.111
	Multifocal	62	18		2.152	0.486–5.965		18		2.384	1.400–3.257
Primary tumor (T)	Ta	89	2	<0.0001*	1	–	0.078	4	<0.0001*	1	–	0.265
	T1	92	9		3.194	0.670–15.225		15		2.577	0.826–8.040
	T2–T4	159	50		5.297	1.156–24.275		51		2.193	0.689–6.979
Nodal metastasis	Negative (N0)	312	42	<0.0001*	1	–	<0.001*	55	<0.0001*	1	–	0.001*
	Positive (N1–N2)	28	19		5.148	2.782–9.526		15		2.940	1.566–5.518
Histological grade	Low grade	56	4	0.0215*	1	–	0.077*	3	0.0027*	1	–	0.066
	High grade	284	57		2.769	0.896–8.554		67		3.219	0.925–11.207
Vascular invasion	Absent	234	24	<0.0001*	1	–	0.304	26	<0.0001*	1	–	0.030*
	Present	106	37		1.387	0.743–2.590		44		1.994	1.070–3.716
Perineural invasion	Absent	321	50	<0.0001*	1	–	<0.001*	61	<0.0001*	1	–	0.015*
	Present	19	11		3.774	1.767–8.062		9		2.640	1.945–8.516
Mitotic rate (per 10 high-power fields)	< 10	173	27	0.167	–	–		30	0.0823	–	–
	≥ 10	167	34		–	–		40		–	–
COMP expression	Low	170	11	<0.0001*	1	–	0.027*	10	<0.0001*	1	–	<0.001*
	High	170	50		2.283	1.100–4.735		60		4.070	1.945–8.516

Note: *Statistically significant.