Table 4. Conformational changes in S1-RBD upon addition of PPS or PPS fractions, determined by far UV-CD.

	P:L ratio	Helix	Antiparallel	Parallel	Turn	Others	NRMSD
PPS	0.0	4.3	35	0.5	12.1	48.0	0.044
	0.2	4.5	37.7	0	12	45.9	0.026
	0.3	4.3	38	0	13.5	44.2	0.025
	0.9	7.3	34.5	2.8	12.3	43.2	0.020
Fr-1.0M	0.0	4.5	35	2.5	12.5	45.6	0.033
	0.2	4.4	35.9	3.1	10.3	46.2	0.036
	0.3	4.1	36.4	0	13.4	46.1	0.026
	0.9	7	36.7	0	13.2	43.2	0.022
Fr-1.2M	0.0	6.4	37.7	0	15.2	40.7	0.044
	0.2	3.8	39.3	0.3	9.5	47.0	0.039
	0.3	8.5	37.5	0.6	9.3	44.1	0.035
	0.9	3.8	39.4	0	14	42.8	0.039
Fr-1.4M	0.0	7.5	37.6	2.3	10.6	42.2	0.034
	0.2	4.7	34.9	2.7	12.1	45.6	0.032
	0.3	4.1	35.4	1.6	14.1	44.7	0.026
	0.9	4.1	35	3.1	11.4	46.3	0.034

Abbreviations: NRMSD, normalized root-mean-square deviation; PPS, pentosan polysulfate; UV-CD, ultraviolet circular dichroism.