Supplementary Table 5. Adjusted HRs (95% CIs) of incident stroke, IS and HS according to groups of 5-year changes in differential leukocyte counts.
| Changes (×109/L) | stroke | Ischemic stroke | Hemorrhagic stroke | |||
|---|---|---|---|---|---|---|
| Events/ Person-years | HR (95% CI) | Events/ Person-years | HR (95% CI) | Events/ Person-years | HR (95% CI) | |
| Neutrophil count change | ||||||
| Q1 (＜–0.65) | 109/14215 | 0.91 (0.71–1.18) | 90/14156 | 0.99 (0.74–1.32) | 19/13929 | 0.64 (0.35–1.18) |
| Q2–Q3 (–0.65 to 0.49) | 218/28969 | 1.00 (ref ) | 171/28823 | 1.00 (ref ) | 47/28468 | 1.00 (ref ) |
| Q4 (＞ 0.49) | 134/14048 | 1.23 (0.99–1.53) | 106/13971 | 1.24 (0.97–1.59) | 28/13755 | 1.20 (0.75–1.92) |
| Lymphocyte count change | ||||||
| Q1 (＜–0.56) | 126/15457 | 1.03 (0.81–1.32) | 97/15373 | 0.93 (0.70–1.23) | 29/15173 | 1.59 (0.92–2.76) |
| Q2–Q3 (–0.56 to 0.07) | 250/27512 | 1.00 (ref ) | 169/27414 | 1.00 (ref ) | 34/26994 | 1.00 (ref ) |
| Q4 (＞ 0.07) | 132/14312 | 1.30 (1.04–1.62) | 101/14211 | 1.21 (0.94–1.55) | 31/14035 | 1.75 (1.07–2.86) |
| Monocyte count change | ||||||
| Q1 (＜–0.26) | 54/6190 | 1.12 (0.79–1.59) | 42/6155 | 1.08 (0.73–1.61) | 12/6066 | 1.27 (0.60–2.70) |
| Q2–Q3 (–0.26 to 0) | 167/25313 | 1.00 (ref ) | 127/25205 | 1.00 (ref ) | 40/24925 | 1.00 (ref ) |
| Q4 (＞ 0) | 59/6477 | 1.37 (1.01–1.86) | 50/6450 | 1.54 (1.10–2.16) | 9/6327 | 0.85 (0.41–1.76) |
| Eosinophil count change | ||||||
| Q1 (＜–0.08) | 32/4705 | 0.85 (0.55–1.31) | 24/4680 | 0.78 (0.47–1.27) | 8/4640 | 1.20 (0.49–2.97) |
| Q2–Q3 (–0.08 to 0.06) | 212/29170 | 1.00 (ref ) | 167/29047 | 1.00 (ref ) | 45/28658 | 1.00 (ref ) |
| Q4 (＞ 0.06) | 36/4093 | 1.03 (0.72–1.49) | 28/4071 | 0.99 (0.65–1.50) | 8/4009 | 1.24 (0.58–2.67) |
Abbreviation: CI, confidence interval; HR, hazard ratio.
HRs were adjusted for age, sex, BMI, education, smoking status, drinking status, physical activity, hypertension, diabetes mellitus, hyperlipidemia, family history of stroke, intake of antibiotics or aspirin, and baseline differential leukocyte counts.