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. 2022 May 7;50(W1):W697–W709. doi: 10.1093/nar/gkac328

Figure 1.

Figure 1.

SigCom LINCS user interface workflow map. SigCom LINCS has several entry points to query the database for mimicking and reversing signatures. Users can submit any search term. The search term can be converted to a gene set using the Geneshot API, or the Enrichr API, or used to retrieve SigCom LINCS signatures. Users of SigCom LINCS can also start with a single human gene. The single human gene can be converted into up and down gene sets using co-expression data from ARCHS4 or submitted for reverse search using two Appyters. Users of SigCom LINCS can also submit a gene set or up and down gene sets for signature search.