Table 1.
Integrated interaction databases and their incorporated edge types
| Name | Data type | Experimental | Literature | Predicted |
|---|---|---|---|---|
| NCG6 | CDG | + | + | + |
| COSMIC | CDG | + | + | - |
| IntOGen | CDG | - | - | + (pipeline) |
| cancer-genes.org | CDG | - | - | + (MutPanning) |
| BioGRID | GGI, DGI | + | + | + |
| STRING | GGI | + | + | + |
| APID | GGI | + | - | - |
| IID | GGI | + | - | + |
| HTRIdb | GGI | + | - | - |
| Reactome | DGI | - | + | - |
| DrugBank | DGI | - | + | - |
| ChEMBL | DGI | + | + | - |
| DGIdb | DGI | + | + | - |
List of databases implemented in CADDIE. Data types are cancer driver gene (CDG), gene-gene interaction (GGI), and drug-gene interaction (DGI). GGIs encompass interactions of corresponding proteins.