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. 2022 May 26;50(W1):W598–W610. doi: 10.1093/nar/gkac426

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Differential contact analysis: (A) Calculation of predicted contacts of each GPCR using the function predict_contacts in the ESM library and grouping GPCR based on G protein binding specificity to compute differential contact maps (log-odds ratio); (B) Projection of transducer family-specific predicted contacts on a structure in PRECOGx application (PDB 7JOZ); (C) Number of aggregated enriched(increase) or depleted(decreased) secondary structure element pairs for each Gprotein transducer family; (D) Contact enrichment signature of each Gprotein transducer family on the basis of secondary structure element.