Figure 4.

(A) Prediction of a missense mutation MC1R/D294H in PRECOGx(upper left); (B) PCA projection of the mutation in GPCRome PCA sequence space(down left); (C) Projection of the mutation on a 3D structure along with predicted contacts for GNAI1(upper right) or GNAS (down right) G proteins; (D)left-panel: attention map of the most important attention head of the best layer for GNAI1 binding prediction; mid-panel: zoom caption of the attention signatures involving the mutated residue (i.e. D294H); right-panel: 3D cylindrical cartoon model (PDB: 7f58) representation of the residue regions involved in attention networks with the D294H site.