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. 2022 May 30;50(W1):W36–W43. doi: 10.1093/nar/gkac446

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Decision workflow of AllerCatPro 2.0 from the query protein to the results of either strong, weak or no evidence for allergenic potential. AllerCatPro 2.0 checks the similarity of the query protein with 714 representatives in our 3D model/structure database of known allergens as well as the most comprehensive dataset of reliable proteins associated with allergenicity (4979 protein allergens). In addition to only comparing the similarity of the query protein with the dataset of known allergens in AllerCatPro 1.7, AllerCatPro 2.0 now predicts the similarity of the query sequence to datasets of 165 autoimmune allergens and 162 low allergenic proteins separately. If a significant sequence similarity is found, then AllerCatPro 2.0 identifies hits of similar proteins associated with autoimmune diseases and/or similar proteins of low allergenic potential and presents the sequence identity to the closest hit.