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Predicted lifetime (age 20–80 years) EOC risk by PV and family history. Each fgure shows the risks assuming the woman is untested, has no PVs or carries a PV in BRCA1, BRCA2, RAD51D, RAD51C or BRIP1. (A) Assuming an unknown family history. (B–E) Assuming an increasing number of affected first-degree relatives, as indicated by the pedigree diagram inserts. Predictions are based on UK EOC population incidence. EOC, epithelial tubo-ovarian cancer; PV, pathogenic variant.
