Table 1.
Summary of components of the EOC risk model
| RF group | RF category | Comments |
| FH | Explicit FH of ovarian and other cancers (breast, prostate, male breast and pancreatic) | Considers families of arbitrary size and structure, including affected and unaffected relatives |
| Sex | Sex of all family members | |
| Age | Ages at cancer diagnosis or current ages/age at death of family members | |
| Genetic factors | ||
| Rare truncating/pathogenic variants | BRCA1 | |
| BRCA2 | ||
| RAD51D | ||
| RAD51C | ||
| BRIP1 | ||
| Common genetic variants | Polygenic Risk Score | Explaining 5% of the polygenic variance |
| Unobserved genetic effects | Residual polygenic component | Accounts for the residual familial aggregation of EOC |
| Lifestyle/hormonal/reproductive | ||
| Height | Measured in cm (five categories) | |
| Body Mass Index | Measured in kg/m2 (three categories) | |
| Parity | Number of live births (three categories) | |
| Endometriosis | Yes/no | |
| Use of oral contraception | Years of use (five categories) | |
| Use of hormone replacement therapy | Never/ever | |
| Tubal ligation | Yes/no | |
| Breast tumour pathology | Oestrogen, progesterone, HER2 receptor, CK14, CK5/6 status | As implemented in the BOADICEA breast cancer model |
| Demographic factors | ||
| Country of origin | Country | Defines the underlying incidences used |
| Birth cohort | Defined by the person’s year of birth | Eight calendar year-specific sets of incidences |
| Family ethnicity | Ashkenazi Jewish origin | |
BOADICEA, Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm; EOC, epithelial tubo-ovarian cancer; FH, family history; RF, risk factor.