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. 2022 Jun 30;55(6):259–266. doi: 10.5483/BMBRep.2022.55.6.064

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Copyright © 2022 by the The Korean Society for Biochemistry and Molecular Biology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1 — Type 1 immunity and metabolism. (A) Metabolic regulation of type 1 immune function. Glycolysis promotes and OXPHOS inhibits M1 macrophage polarization. Both glycolysis and OXPHOS metabolic pathway (aerobic glycolysis) support Th1 differentiation and function. (B) Type 1 immune regulation of metabolic function. Inflammatory cytokines such as IL-1β, TNF-α, and IL-6 provoke systemic insulin resistance. IL-6 induce lipid oxidation in muscles. Type 1 interferon inhibits insulin resistance and obesity. Type 1 interferon promotes glucose uptake in embryonic fibroblast and fatty acid oxidation in plasmacytoid DC.