Table 8.

Cytogenetic and molecular abnormalities defining acute myeloid leukaemia, myelodysplasia-related.

Defining cytogenetic abnormalities
Complex karyotype (≥3 abnormalities)
5q deletion or loss of 5q due to unbalanced translocation
Monosomy 7, 7q deletion, or loss of 7q due to unbalanced translocation
11q deletion
12p deletion or loss of 12p due to unbalanced translocation
Monosomy 13 or 13q deletion
17p deletion or loss of 17p due to unbalanced translocation
Isochromosome 17q
idic(X)(q13)
Defining somatic mutations
ASXL1
BCOR
EZH2
SF3B1
SRSF2
STAG2
U2AF1
ZRSR2