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. 2022 May 18;36(7):1759–1768. doi: 10.1038/s41375-022-01587-0

Fig. 4. T-ALL type-2 relapses have undergone stronger chromatin remodeling and transcriptional changes than type-1 relapses.

Fig. 4

A Differential analyses (DESeq2, adj p < 0.05) of RNA-Seq and ATAC-Seq datasets comparing initial diagnosis and relapse within type-1 and type-2 leukemias. MA plots show log2 fold changes in expression/accessibility in relation to the mean of normalized counts per gene/peak. Significantly differential expressed genes/accessible ATAC-peaks are labeled in red. B Deconvolution analysis of T-ALL samples performed with CIBERSORT trained on the signature of 2823 open chromatin regions selected to distinguish five differentiation stages (DN2, DN3/ISP, DPCD3–/ DPCD3+, CD4+, CD8+) of healthy T-cell precursors as previously reported [35] and applied to decompose T-ALL ATAC-profiles. C Fraction of the dominant population as predicted by deconvolution with CIBERSORT in T-ALLs relapsing either as type-1 or type-2.