Table 2.
Differential fatty acids of the full-thickness skin between keloid and normal skin.
| Metabolite | VIP | p value | Expressiona |
|---|---|---|---|
| Fatty acids | |||
| Ethylmethylacetic acid | 2.15 | <0.0001 | Down |
| 2-Hydroxy-3-methylbutyric acid | 1.74 | 0.0004 | Up |
| Formic acid | 1.68 | 0.0008 | Down |
| Docosapentaenoic acid | 1.64 | 0.0011 | Up |
| Arachidonic acid | 1.64 | 0.0011 | Up |
| Eicosapentaenoic acid | 1.57 | 0.0021 | Up |
| 2-Methylvaleric acid | 1.54 | 0.0026 | Down |
| 5-Dodecenoic acid | 1.46 | 0.0050 | Down |
| 8,11,14-Eicosatrienoic acid | 1.43 | 0.0061 | Up |
| Adrenic acid | 1.43 | 0.0064 | Up |
| Itaconic acid | 1.34 | 0.0118 | Down |
| Myristoleic acid | 1.33 | 0.0123 | Down |
| 10Z-Nonadecenoic acid | 1.32 | 0.0132 | Up |
| Methylglutaric acid | 1.32 | 0.0132 | Down |
| DPAn-6 | 1.28 | 0.0166 | Up |
| Docosahexaenoic acid | 1.28 | 0.0166 | Up |
| Alpha-Linolenic acid | 1.26 | 0.0185 | Down |
| Isocaproic acid | 1.24 | 0.0212 | Down |
| Heptanoic acid | 1.17 | 0.0307 | Down |
| 12-Hydroxystearic acid | 1.02 | 0.0644 | Down |
| Dodecanoic acid | 1.02 | 0.0653 | Down |
| Sebacic acid | 1.00 | 0.0697 | Down |
| Short-chain fatty acids | |||
| Isobutyric acid | 2.05 | ＜0.0001 | Down |
| Butyric acid | 1.62 | 0.0014 | Down |
| Valeric acid | 1.48 | 0.0045 | Down |
| Isovaleric acid | 1.43 | 0.0065 | Down |
| Malonic acid | 1.37 | 0.0094 | Down |
VIP: variable influence on projection.
a
“down” means the expression of this fatty acid in keloid was lower than that in normal skin; on the contrary, “up” means this fatty acid in keloid was higher expression.