Table 2.

Common muscle disease module (CMDM) genes.

Gene symbol	Summary effect size in discovery set	Summary effect size in validation set	Summary effect size in secondary validation set
CHRNA1	1.31	1.125	1.796
LGMN	1.27	1.14	1.114
MYH8	1.161	1.241	2.009
C1R	1.094	0.924	0.743
AKR1A1	1.041	0.879	2.603
CDKN1A	1.04	1.009	1.855
CILP	0.993	1.189	1.01
TNFRSF21	0.992	0.942	0.464
OSBPL8	0.981	0.827	1.309
KLHL2	0.961	0.894	2.101
TMEM208	0.946	0.47	0.83
TMEM87A	0.94	0.49	0.671
IFITM2	0.932	0.599	0.195
C3	0.892	1.083	0.801
DUSP22	0.88	0.635	0.07
DDOST	0.855	0.308	0.321
LETMD1	0.847	0.844	0.563
CETN2	0.835	0.712	0.792
GPX3	0.833	0.549	− 0.252
ITPA	0.821	0.468	0.865
CLTC	0.808	0.633	0.894
SCPEP1	0.796	0.767	0.099
HEXA	0.789	0.54	− 0.145
SAE1	0.787	0.549	1.234
CHI3L1	0.765	0.442	− 0.44
USP3	0.76	0.386	0.619
HSP90B1	0.754	0.373	0.169
CKAP4	0.752	0.46	0.638
FST	0.747	0.923	1.546
NIP7	0.742	0.243	− 0.076
PANX1	0.737	0.666	0.389
HEY1	0.737	0.37	0.828
TBC1D16	0.726	0.571	0.84
TRMT112	0.711	0.475	0.698
TPP1	0.698	0.586	− 0.092
CERS2	0.673	0.158	0.793
ATP2A1	− 0.696	− 0.192	− 1.703
CS	− 0.71	− 0.673	0.185
ALDOA	− 0.719	− 0.428	− 1.847
SH2B2	− 0.721	− 0.724	− 0.573
PTP4A1	− 0.75	− 0.568	− 0.259
ACADSB	− 0.751	− 0.356	− 0.814
FXYD1	− 0.754	− 0.534	0.013
ATP5F1D	− 0.762	− 0.603	− 0.03
CAPN3	− 0.774	− 0.525	0.399
DUSP26	− 0.792	− 0.661	− 0.388
SLC25A12	− 0.834	− 0.479	− 0.32
TAPT1	− 0.865	− 0.37	− 0.506
GOT2	− 0.88	− 0.612	− 0.3
PYGM	− 0.956	− 0.432	− 1.556
LRRC20	− 0.968	− 0.635	− 0.208
CAMK2G	− 0.996	− 0.652	− 0.445

Genes are listed from the largest absolute meta-effect size to the smallest (from summary effect size in discovery set).