Table 3.
Associations of common muscle disease module (CMDM) scores with clinical and histological measures of disease severity.
| Cohort | Disease category | Clinic measure correlated to CMDM score | Correlation r | p-value |
|---|---|---|---|---|
| GSE109178 | Congenital | Mild fibrosis vs no fibrosis | – | 2.68 × 10–5 |
| GSE109178 | Congenital | Moderate fibrosis vs no fibrosis | – | 6.66 × 10–4 |
| GSE109178 | Congenital | Severe fibrosis vs no fibrosis | – | 1.49 × 10–5 |
| EMEXP3260 | MND | Muscle atrophy | 0.88 | 1.62 × 10–3 |
| EMEXP3260 | MND | Muscle strength | −0.77 | 0.014 |
| EMEXP3260 | MND | Early ALS vs controls | – | 0.84 |
| EMEXP3260 | MND | Late ALS vs controls | – | 0.019 |
| GSE78929 | ICUAW | Functional independence measure (FIM) motor subscore | −0.59 | 3.10 × 10–3 |
| GSE78929 | ICUAW | Quadriceps muscle mass | −0.50 | 0.011 |
| GSE78929 | ICUAW | Early ICUAW (day 7 post-ICU discharge) vs controls | – | 2.50 × 10–5 |
| GSE78929 | ICUAW | Sustained ICUAW (month 6 post-ICU discharge ) vs controls | – | 9.14 × 10–5 |
| GSE34111 | Chronic | Quadriceps muscle strength | −0.09 | 0.73 |