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a Venn diagram depicts overlap in upregulated metabolites at T24 versus Pre and upregulated metabolites at T48 versus Pre. Fold change >1.5. b Venn diagram depicts overlap in downregulated metabolites at T24 versus Pre and downregulated metabolites at T48 versus Pre. Fold change <0.67. c The enrichment of top 20 metabolic pathways according to the identified distinguished metabolites at four time points by MetaboAnalyst (v5.0).
