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. 2021 Nov 22;43(7):1686–1698. doi: 10.1038/s41401-021-00806-1

Fig. 2. Attenuation of METH-induced CPP is not dependent on dose or time of METH treatment in Clk1-deficient mice.

Fig. 2

The CPP procedure was performed as described in Fig. 1a and Methods. a Clk1+/− mutant mice were divided into three groups: saline, METH 2 mg/kg, and METH 4 mg/kg. Each group received 4 consecutive days of injections in the conditioning phase. Then, following a post-conditioning test, CPP scores were calculated (n = 8–9 animals per group). b After this post-conditioning test, the group receiving METH 2 mg/kg received an additional 4 consecutive days of injections in the conditioning phase (i.e., a total of 8 days). Then, following another post-conditioning test, CPP scores were again calculated (n = 8–9 animals per group). Bar graphs are presented as means ± SEM. Statistical analysis was performed using one-way ANOVA followed by Bonferroni-corrected tests (*P < 0.05 vs saline; NS not significant).