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. 2021 Nov 22;43(7):1686–1698. doi: 10.1038/s41401-021-00806-1

Fig. 7. Schematic diagram to indicate possible mechanisms underlying Clk1 deficiency-mediated inhibition in acquisition of METH-induced CPP.

Fig. 7

Clk1 deficiency inhibits transcription of hepcidin by HIF-1α and then efflux of iron is promoted by upregulation of FPN1. In addition, expression of each of Rab 5, EEA1 and LAMP 1 is reduced. Finally, iron deficiency down-regulates PKC activity and suppresses DAT lysosomal degradation, thus decreasing DA concentration to inhibit acquisition of METH-induced CPP.