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. 2021 Nov 17;43(7):1780–1792. doi: 10.1038/s41401-021-00797-z

Fig. 6. AC treatment alleviated LPS plus ATP-mediated inflammatory responses in mice.

Fig. 6

a The inducement of in vivo acute inflammation model using LPS plus ATP. DEX: 4 mg/kg DEX; AC-L: 20 mg/kg AC; AC-H: 60 mg/kg AC; EX-527: 10 mg/kg EX-527; AC + EX-527: 60 mg/kg AC and 10 mg/kg EX-527. n = 3‒5. b Changes of body weight. The serum levels of IL-1β (c), IL-6 (d), MCP-1 (e), and TNF-α (f). g NLRP3, cleaved IL-1β, and cleaved caspase 1 levels in peritoneal macrophages were analyzed by Western blotting. GAPDH was chosen as an internal loading control. Data are expressed as means ± SEM. #P < 0.05 LPS + ATP vs. vehicle; *P < 0.05, **P < 0.01, ***P < 0.001 AC-L, AC-H or DEX vs. LPS + ATP.