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. 2021 Nov 16;43(7):1816–1828. doi: 10.1038/s41401-021-00787-1

Fig. 2. Omeprazole suppresses EMT and EMT-associated tumor metastasis in vivo.

Fig. 2

a, b Immunofluorescence staining of E-cadherin and vimentin in HCT116 xenograft tumors and PyMT primary tumors; the staining intensity of the tumors was quantified (n = 6). c The levels of Snail, E-cadherin and vimentin in tumor lysates were evaluated by immunoblotting (n = 3 pools from six mice). d, e Representative photographs of metastatic nodules (top), GFP fluorescence (middle), and H&E staining (bottom) of livers; the fluorescence intensity of the livers was quantified (n = 6). f, g Representative H&E staining images of lungs from MMTV-PyMT mice; lung nodules were quantified (n = 6). h, i Representative H&E staining images of the lungs of BALB/c mice; lung nodules were quantified (n = 6). j Representative H&E staining images of bone sections from BALB/c mice (n = 6). T, tumor cells; B, bone. k, l Representative TRAP staining images of bone sections from BALB/c mice; the staining intensity was quantified (n = 6). Data are presented as the mean ± SD. Two-tailed Student’s t test was used for statistical analysis. **P < 0.01 vs. vehicle.