Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 4;13:3835. doi: 10.1038/s41467-022-31476-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 10 — a Experiment design for serine administration via drinking water. b, c Concentrations of serine, glycine, TG and cholesterol in the serum of indicated groups, n = 9, 6 independent animals for HFD or HFD + Ser group, respectively (mean ± SD). ^**P_serine = 0.0053; ^*P_TG = 0.0363 (unpaired, two-tailed t-test). d–h H&E staining (d) with quantitative data for relative glomerular area (e), serine and glycine concentration (f), renal TG and cholesterol levels (g), and transcriptional levels of TG synthesis/lipid storage related genes (h) in the kidney of indicated groups, data shown as mean ± SD. e n = 9, 5 independent animals for HFD or HFD + Ser group, respectively, ^**P_H&E = 0.0059; f, g n = 9, 6 independent animals for HFD or HFD + Ser group, respectively, ^**P_glycine = 0.0073; ^***P_TG < 0.0001, ^***P_Cholesterol < 0.0001; (h) n = 8, 6 independent animals for HFD or HFD + Ser group, respectively, ^***P_Mogat1 = 0.0005; ^**P_Gpam = 0.0049; ^*P_Cidea = 0.01; ^*P_Cidec = 0.0495 (unpaired, two-tailed t-test). i–m H&E staining (i), with quantitative data for relative liver steatosis score (j), serine and glycine concentration (k), hepatic TG and cholesterol levels (l) and transcriptional levels of TG synthesis/lipid storage related genes (m) in the liver of indicated groups, data shown as mean ± SD. j n = 9, five independent animals HFD or HFD + Ser group, respectively, ^*P_H&E = 0.0197; (k–l) n = 9, 6 independent animals for HFD or HFD + Ser group, respectively, ^*P_serine = 0.0377; ^*P_TG = 0.0437, ^***P_Cholesterol < 0.0001; (m) n = 8, 6 independent animals for HFD or HFD + Ser group, respectively, ^***P_Mogat1 = 0.0008, ^*P_Cidea = 0.0495, ^**P_Cidec = 0.0072 (unpaired, two-tailed t-test). n Possible mechanisms in present study. Scale bar, 50 μm. Source data are provided in the Source Data file.