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. 2022 Jul 4;13:3835. doi: 10.1038/s41467-022-31476-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b H&E and PAS staining on renal sections of indicated groups (a), with quantitative data for relative glomerular area and relative mesanglial area (b), data shown as mean ± SD. n_H&E = 5, 6, 8, 5 independent animals for WT + NC or Utx^Ksp KO + NC or WT + HFD or Utx^Ksp KO + HFD group, respectively, ^**P_{H&E (WT+NC vs WT+HFD)} = 0.0075, ^*P_{H&E (WT+HFD vs Utx}^Ksp _KO+HFD) = 0.0419; n_PAS = 5, 4, 8, 4 independent animals for WT + NC or Utx^Ksp KO + NC or WT + HFD or Utx^Ksp KO + HFD group, respectively, ^*P_{PAS (WT+NC vs WT+HFD)} = 0.0211, ^*P_{PAS (WT+HFD vs Utx}^Ksp _KO+HFD) = 0.0405 (one-way ANOVA). Scale bar, 50 μm. c, d TG (triglycerides) and cholesterol levels in renal medulla (c) and cortex (d) of the indicated groups; n = 6, 6, 7, 5 independent animals, for WT + NC or Utx^Ksp KO + NC or WT + HFD or Utx^Ksp KO + HFD group, respectively (mean ± SD). c ^***P_{TG (WT+NC vs WT+HFD)} < 0.0001, ^***P_{TG (WT+HFD vs Utx}^Ksp _KO+HFD) < 0.0001; ^***P_{Cholesterol (WT+NC vs WT+HFD)} = 0.0009, ^***P_{Cholesterol (WT+HFD vs Utx}^Ksp _KO+HFD) = 0.0006; d ^***P_{TG (WT+NC vs WT+HFD)} < 0.0001, ^***P_{TG (WT+HFD vs Utx}^Ksp _KO+HFD) < 0.0001; ^***P_{Cholesterol (WT+NC vs WT+HFD)} < 0.0001, ^***P_{Cholesterol (WT+HFD vs Utx}^Ksp _KO+HFD) = 0.0001 (one-way ANOVA). e, f Transcriptional levels of TG synthesis/lipid storage related genes in renal medulla (e) and cortex (f) of the indicated groups; n = 3 independent animals (mean ± SD). e ^**P_{Mogat1(WT+NC vs WT+HFD)} = 0.0033; ^***P_{Gpam (WT+NC vs WT+HFD)} = 0.0001, ^*P_{Gpam (WT+HFD vs Utx}^Ksp _KO+HFD) = 0.0294; ^***P_{Cidea (WT+NC vs Utx}^Ksp _KO+NC) = 0.0004, ^**P_{Cidea (WT+HFD vs Utx}^Ksp _KO+HFD) = 0.0015; ^***P_{Cidec (WT+NC vs Utx}^Ksp _KO+NC) < 0.0001, ^*P_{Cidec(WT+HFD vs Utx}^Ksp _KO+HFD) = 0.0402; f ^**P_{Mogat1 (WT+NC vs WT+HFD)} = 0.0018, ^*P_{Mogat1(WT+HFD vs Utx}^Ksp _KO+HFD) = 0.0204; ^**P_{Gpam (WT+NC vs WT+HFD)} = 0.0072, ^**P_{Gpam (WT+HFD vs Utx}^Ksp _KO+HFD) = 0.0097; ^**P_{Cidea (WT+NC vs Utx}^Ksp _KO+NC) = 0.0013, ^*P_{Cidea (WT+HFD vs Utx}^Ksp _KO+HFD) = 0.0188; ^*P_{Cidec (WT+NC vs Utx}^Ksp _KO+NC) = 0.0279, ^***P_{Cidec (WT+HFD vs Utx}^Ksp _KO+HFD) = 0.0003 (one-way ANOVA). Source data are provided in the Source Data file.