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. 2022 Jul 4;13:3854. doi: 10.1038/s41467-022-31285-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Cryo-EM density map of human Kv1.3. B The pore region of Kv1.3 as modeled with C4 symmetry (left), as seen in the density map refined with C4 symmetry (middle) or as modeled with C1 symmetry (right). This panel highlights the presence of three K⁺ ion densities and the equivalent ion occupancy when using C1 and C4 symmetries. K⁺ ions shown in green. C Model of human Kv1.3 with C4 symmetry constraints. The transmembrane (TM) region and T1 domains are indicated. Model of Kv1.3 with the voltage sensing domains (VSDs) colored (D), or with the pore domain colored (E). The front and rear VSDs are omitted for clarity in E.