Fig. 5. DAPA inhibited chondrocyte apoptosis in Ang II-stimulated cardiomyocytes.

a, b The protein levels of Bcl-2, Bax, and cleaved caspase 3 in each group were determined. c, d Flow cytometry was used to assess the apoptosis of cardiomyocytes labeled with Annexin V and PI fluorescence. e–k The protein expression levels and optical density analysis of SIRT1, p-PERK, ATF4, GRP-78, p-eIF2α, and CHOP in the myocardium. n = 6, ^∗P < 0.05 versus the CON or DAPA group, ^#P < 0.05 versus the Ang II.