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. 2021 Dec 1;43(7):1721–1732. doi: 10.1038/s41401-021-00805-2

Fig. 7. EX527 abrogated the inhibitory effect of DAPA on Ang II-induced ER stress in cardiomyocytes.

Fig. 7

a, b The protein levels of Bcl-2, Bax, and cleaved caspase 3 in each group were detected. c CHOP immunofluorescence staining. Markedly increased green bright puncta indicated the upregulated expression of CHOP. d Quantification of the number of CHOP-positive chondrocytes in each group based on immunofluorescence staining. e–k The protein expression levels and optical density analysis of SIRT1, p-PERK, ATF4, GRP-78, p-eIF2α, and CHOP in the myocardium. n = 6, ∗P < 0.05 versus the Ang II or Ang II + EX527 group, #P < 0.05 versus the Ang II + DAPA group.