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. 2021 Dec 1;43(7):1721–1732. doi: 10.1038/s41401-021-00805-2

Fig. 8. DAPA inhibited cardiomyocyte apoptosis and ER stress in the TAC model.

Fig. 8

a, b The protein levels of Bcl-2, Bax, and cleaved caspase 3 in each group were determined. c, d TUNEL staining of apoptotic cardiomyocytes and quantification of TUNEL staining in each group. ek The protein expression levels and optical density analysis of SIRT1, p-PERK, ATF4, GRP-78, p-eIF2α, and CHOP in the myocardium. n = 6, P < 0.05 versus the sham or DAPA group, #P < 0.05 versus the TAC.