a, b The protein levels of Bcl-2, Bax, and cleaved caspase 3 in each group were determined. c, d TUNEL staining of apoptotic cardiomyocytes and quantification of TUNEL staining in each group. e–k The protein expression levels and optical density analysis of SIRT1, p-PERK, ATF4, GRP-78, p-eIF2α, and CHOP in the myocardium. n = 6, ∗P < 0.05 versus the sham or DAPA group, #P < 0.05 versus the TAC.