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. 2021 Nov 18;43(7):1829–1842. doi: 10.1038/s41401-021-00799-x

Fig. 2. ADT-OH inhibits melanoma invasion in vivo in mice tail vein injection model.

Fig. 2

a Animal treatment methods. b Representative lung imaging of mice after tail vein injection with B16F10 cells for 3 weeks. c H&E stained lung sections. The representative images showed lung tumor distribution of the lung metastasis model mice treated with vehicle, 18.75 mg/kg ADT-OH, 37.5 mg/kg ADT-OH, 75 mg/kg ADT-OH, 1.4 mg/kg NaHS, 2.8 mg/kg NaHS or 5.6 mg/kg NaHS. Scale bars, 100 μm. d–e Representative lung imaging (d) and H&E tissue staining (e) of mice injected with A375 cells via the tail vein. The lung metastasis model mice were treated with vehicle, 37.5 mg/kg ADT-OH, 75 mg/kg ADT-OH or 2.8 mg/kg NaHS for 3 weeks. Scale bars, 100 μm.