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. 2021 Nov 18;43(7):1829–1842. doi: 10.1038/s41401-021-00799-x

Fig. 7. ADT-OH regulates the protein level of FAK mainly through decreasing the mRNA stability of FAK.

Fig. 7

a The FAK mRNA levels of B16F10, B16F1 and A375 cells were detected by qPCR analysis after ADT-OH treatment for 6 h, respectively. b Detection of FAK promoter transcriptional activity after ADT-OH treatment with dual luciferase in B16F10, B16F1 and A375 cells. c B16F10, B16F1 and A375 cells were treated with or without Act D (0.05 μg/mL) and ADT-OH (6.3 μM) for 12 h, and then the mRNA levels of FAK were detected. *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.001. Data are expressed as mean ± SD of three independent experiments.