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. 2022 Jul 4;12:11290. doi: 10.1038/s41598-022-15578-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The top five overlapping hub genes of clustering modules in the protein–protein interaction network of differentially expressed genes from (A) musculoskeletal aging and (B) Alzheimer’s disease. Yellow nodes constitute hub genes. MRPL15 Mitochondrial ribosomal protein L15, NDUFAB1 NADH:ubiquinone oxidoreductase subunit AB1, NDUFS3 NADH:ubiquinone oxidoreductase core subunit S3, UQCRC1 Ubiquinol-cytochrome c reductase core protein 1, UQCRFS1 Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1.