Table 1.
The top five ranked and overlapping hub genes according to 11 topological algorithms in the protein–protein interaction networks of musculoskeletal aging and Alzheimer’s disease differentially expressed genes.
| Gene ID | Gene name | Musculoskeletal aging | Alzheimer’s disease | ||
|---|---|---|---|---|---|
| P value | Z-Score | P value | logFC | ||
| NDUFAB1 | NADH:ubiquinone oxidoreductase subunit AB1 | 3.14E−02 | − 3.04 | 3.59E−16 | 1.34 |
| UQCRC1 | ubiquinol-cytochrome c reductase core protein 1 | 4.65E−02 | − 2.86 | 1.10E−11 | 1.64 |
| UQCRFS1 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | 1.31E−06 | − 5.88 | 9.91E−15 | 1.36 |
| NDUFS3 | NADH:ubiquinone oxidoreductase core subunit S3 | 3.08E−03 | − 3.88 | 8.30E−10 | 1.09 |
| MRPL15 | mitochondrial ribosomal protein L15 | 9.93E−04 | − 4.23 | 3.71E−07 | 1.40 |
FC Fold change.