Table 3.
Hemolysis results and selectivity index of cationic tricyclic and tetracyclic compounds against bacterial strains S. aureus (ATCC-29213), E. coli (ATCC-25922), and P. aeruginosa (ATCC-27853).
| Structure Core |
FAI (charge/ring) | HC50 (μg/mL) | IC50 (μg/mL) |
S. aureus |
E. coli |
P. aeruginosa |
|---|---|---|---|---|---|---|
| Selectivity Index (HC50/MIC) | ||||||
| Tricyclic (Abietic Acid) | 1/3 | 160 | 133 | 21 | 10 | 3 |
| 2/3 | >1000 | >250 | >32 | >4 | N/A | |
|
3/3 |
>1000 |
>250 |
>32 |
>8 |
N/A |
|
| Tetracyclic (Bile Acid) | 2/4 | 205 | 48 | 410 | 205 | 3 |
| 3/4 | > 1000 | >250 | > 500 | > 64 | > 4 | |
| 4/4 | >1000 | >250 | >32 | >16 | >4 | |