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. 2022 Jun;12(3):340–351. doi: 10.21037/cdt-21-724

Figure 2.

Figure 2

MI mice show depression-like behaviors, but GSK J4 protects MI mice from developing these behaviors. (A) Immobility time in the TST was examined at 2 weeks after ligation. DMSO-treated MI mice showed significantly longer immobility times than did DMSO-treated sham-operated mice and GSK J4-treated mice. *, denotes a significantly shorter immobility time in the GSK J4-treated MI mice (123.50±6.62 s) and DMSO-treated sham-operated mice (134.50±5.86 s) than in the DMSO-treated MI mice (233.63±10.05 s; P<0.001). (B) Immobility time in the FST was examined at 2 weeks after ligation. DMSO-treated MI mice showed a significantly longer immobility time (135.83±14.913 s) than did DMSO-treated sham-operated mice (63.26±7.736 s; P<0.001). GSK J4 significantly reduced the immobility time of the MI mice. *, denotes a significantly shorter immobility time in the GSK J4-treated MI mice (73.13±5.00 s) and GSK J4-treated sham-operated mice (75.36±9.06 s) than in the DMSO-treated MI mice (135.83±14.913 s; P<0.001). n=10 per group. Data are presented as mean ± SD. TST, tail-suspension test; MI, myocardial infarction; DMSO, dimethylsulfoxide; FST, forced swimming test; SD, standard deviation.