Table 2.
Generalized estimating equation analysis for the comparison of outcomes
| Instrument | T0 (n = 136) | T1 (n = 124) | T2 (n = 123) | Wald Chi-square | P | |
|---|---|---|---|---|---|---|
| HADS-anxiety | Control | 4.62 ± 2.96 | 4.37 ± 2.89 | 4.68 ± 2.46 | 1.548 | 0.213 |
| Experimental | 4.56 ± 2.98 | 3.18 ± 2.76 | 4.43 ± 2.80 | 28.133 | < 0.001* | |
| LS mean (95% CI) | 0.06 (− 0.97, 1.10) | 1.18 (0.20, 2.17) | 0.25 (− 0.67, 1.17) | |||
| Wald Chi-square | 301.447 | 216.258 | 373.153 | |||
| P | 0.907 | 0.018* | 0.594 | |||
| HADS-depression | Control | 4.57 ± 2.80 | 4.6 ± 3.20 | 5.02 ± 2.68 | 1.232 | 0.267 |
| Experimental | 4.25 ± 3.28 | 3.11 ± 2.57 | 4.11 ± 2.98 | 21.888 | < 0.001* | |
| LS mean (95% CI) | 0.33 (− 0.74, 1.39) | 1.49 (0.48, 2.50) | 0.90 (− 0.09, 1.90) | |||
| Wald Chi-square | 263.847 | 209.848 | 317.061 | |||
| P | 0.549 | 0.004* | 0.076 | |||
| RPFS-CV | Control | 2.31 ± 0.15 | 1.91 ± 0.17 | 2.31 ± 0.14 | 4.765 | 0.092 |
| Experimental | 2.07 ± 0.17 | 1.69 ± 0.17 | 2.04 ± 0.17 | 10.845 | 0.004* | |
| LS mean (95% CI) | 0.24 (− 0.21, 0.69) | 0.23 (− 0.24, 0.69) | 0.27 (− 0.16, 0.71) | |||
| Wald Chi-square | 1.069 | 0.921 | 1.513 | |||
| P | 0.301 | 0.337 | 0.219 | |||
| BPI-C | Control | 3.47 ± 0.40 | 3.72 ± 0.43 | 3.04 ± 0.38 | 6.092 | 0.048* |
| Experimental | 3.13 ± 0.37 | 2.61 ± 0.40 | 2.36 ± 0.30 | 8.914 | 0.012* | |
| LS mean (95% CI) | 0.30 (− 0.76, 1.36) | 1.11 (− 0.05, 2.27) | 0.68 (− 0.27, 1.62) | |||
| Wald Chi-square | 0.309 | 3.534 | 1.981 | |||
| P | 0.579 | 0.060 | 0.159 | |||
| FACT-B | Control | 91.4 ± 16.68 | 96.9 ± 15.96 | 90.89 ± 15.74 | 12.925 | < 0.001* |
| Experimental | 95.87 ± 16.06 | 103.25 ± 15.37 | 96.34 ± 16.05 | 20.937 | < 0.001* | |
| LS mean (95% CI) | − 4.47 (− 10.19, 1.24) | − 6.34 (− 11.81, − 0.87) | − 5.46 (− 11.03, 0.12) | |||
| Wald Chi-square | 4038.735 | 4929.180 | 4209.628 | |||
| P | 0.125 | 0.023* | 0.055 | |||
* P ≤ 0.05 indicated statistically significant difference