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. 2022 Jun 21;13:879690. doi: 10.3389/fphar.2022.879690

FIGURE 8.

FIGURE 8

SHY-01 promotes long-term functional recovery of rats with tMCAO. SHY-01 (SHY, 50 mg/kg/day) or metformin hydrochloride (Met, 50 mg/kg/day) was administrated (i.p.) every 24 h post reperfusion, saline was used as vehicle control, rats were sacrificed at 4 weeks after tMCAO. (A) Timeline of SHY or Met treatments during neurologic recovery over the period of 4 weeks post-stroke. (B) Representative images of rat brain sections stained with TTC. (C) Brain atrophy was quantified, and (D) neurologic scores were analyzed in each group. n = 12 rats/group, data are expressed as mean ± SD, statistical analysis was performed with one-way ANOVA, followed by a Dunnett’s post hoc tests. ∗∗ p < 0.01 versus tMCAO treated with vehicle group; # p < 0.05, versus tMCAO with SHY-treated group. Behaviors of (E) Morris water maze test and (F) rope climbing test were evaluated, (G) weight changes were recorded for 4 weeks post-ischemia. Results are expressed as medium ± SEM (n = 8/group). Statistical analysis in each time point was performed by statistical analysis was performed with one-way ANOVA, followed by a Dunnett’s post hoc tests. ∗ p < 0.05, ∗∗ p < 0.01 versus vehicle group; # p < 0.05 versus SHY-treated group.