TABLE 10.
The association between the blood chemistry parameters and Golden-Antrodia Camphorata (Safety set).
| Parameters | Treatment | Test | Placebo | p-value | ||
|---|---|---|---|---|---|---|
| N = 53 | N = 51 | |||||
| N | Mean ± SD | N | Mean ± SD | |||
| Na (mmol/L) | Baseline (Visit 2) | 53 | 141.68 ± 1.87 | 51 | 141.53 ± 2.01 | 0.7741 b |
| 12w (Visit 4) | 43 | 140.84 ± 1.99 | 44 | 140.82 ± 1.98 | ||
| Change from baseline | 43 | -0.81 ± 2.07 | 44 | -0.84 ± 1.84 | 0.9490 a | |
| p-value c | 0.0137 | 0.0041 | ||||
| K (mmol/L) | Baseline (Visit 2) | 53 | 4.31 ± 0.40 | 51 | 4.31 ± 0.42 | 0.6595 b |
| 12w (Visit 4) | 43 | 4.28 ± 0.40 | 44 | 4.33 ± 0.35 | ||
| Change from baseline | 43 | 0.00 ± 0.47 | 44 | -0.01 ± 0.52 | 0.5460 b | |
| p-value | 1.0000 c | 0.9340 d | ||||
| Cl (mmol/L) | Baseline (Visit 2) | 53 | 102.45 ± 2.22 | 51 | 102.14 ± 2.46 | 0.6648 b |
| 12w (Visit 4) | 43 | 102.67 ± 2.10 | 44 | 102.30 ± 2.04 | ||
| Change from baseline | 43 | 0.30 ± 2.46 | 44 | -0.18 ± 2.63 | 0.3788 a | |
| p-value c | 0.4257 | 0.6495 | ||||
| Ca (mg/dl) | Baseline (Visit 2) | 53 | 9.51 ± 0.43 | 51 | 9.52 ± 0.44 | 0.9403 a |
| 12w (Visit 4) | 43 | 9.40 ± 0.48 | 44 | 9.46 ± 0.44 | ||
| Change from baseline | 43 | -0.10 ± 0.37 | 44 | -0.09 ± 0.40 | 0.9137 a | |
| p-value c | 0.0875 | 0.1433 | ||||
| CK (IU/L) | Baseline (Visit 2) | 53 | 719.68 ± 4451.37 | 51 | 118.47 ± 49.52 | 0.3507 b |
| 12w (Visit 4) | 43 | 121.51 ± 81.26 | 44 | 117.64 ± 45.15 | ||
| Change from baseline | 43 | 10.70 ± 69.07 | 44 | -0.89 ± 45.50 | 0.3438 b | |
| p-value | 0.2849 d | 0.8978c | ||||
| Protein (g/dl) | Baseline (Visit 2) | 53 | 7.26 ± 0.36 | 51 | 7.25 ± 0.38 | 0.8565 a |
| 12w (Visit 4) | 43 | 7.20 ± 0.35 | 44 | 7.19 ± 0.40 | ||
| Change from baseline | 43 | -0.06 ± 0.34 | 44 | -0.06 ± 0.40 | 0.9679 a | |
| p-valuec | 0.2738 | 0.3140 | ||||
| Albumin (g/dl) | Baseline (Visit 2) | 53 | 4.64 ± 0.23 | 51 | 4.66 ± 0.25 | 0.4125 b |
| 12w (Visit 4) | 43 | 4.60 ± 0.23 | 44 | 4.65 ± 0.23 | ||
| Change from baseline | 43 | -0.04 ± 0.25 | 44 | 0.00 ± 0.26 | 0.4945 a | |
| p-value c | 0.2962 | 0.9542 | ||||
| Glucose (mg/dl) | Baseline (Visit 2) | 53 | 99.94 ± 16.11 | 51 | 107.35 ± 43.61 | 0.4823 b |
| 12w (Visit 4) | 43 | 103.30 ± 15.70 | 44 | 103.00 ± 20.43 | ||
| Change from baseline | 43 | 2.84 ± 13.43 | 44 | 3.75 ± 20.79 | 0.6191 b | |
| p-value d | 0.3670 | 0.1279 | ||||
| T.Bilirubin (mg/dl) | Baseline (Visit 2) | 53 | 0.78 ± 0.37 | 51 | 0.77 ± 0.35 | 1.0000 b |
| 12w (Visit 4) | 43 | 0.70 ± 0.38 | 44 | 0.74 ± 0.36 | ||
| Change from baseline | 43 | -0.09 ± 0.35 | 44 | -0.07 ± 0.29 | 0.4273 b | |
| p-value | 0.0889c | 0.2041 d | ||||
| ALP (IU/L) | Baseline (Visit 2) | 53 | 151.53 ± 92.64 | 51 | 147.51 ± 85.67 | 0.9922 b |
| 12w (Visit 4) | 43 | 146.86 ± 84.60 | 44 | 142.32 ± 87.41 | ||
| Change from baseline | 43 | -5.12 ± 28.17 | 44 | 2.34 ± 22.89 | 0.4942 b | |
| p-value d | 0.2605 | 0.9908 | ||||
| Creatinine (mg/dl) | Baseline (Visit 2) | 53 | 0.93 ± 0.16 | 51 | 0.91 ± 0.16 | 0.5198 a |
| 12w (Visit 4) | 43 | 0.90 ± 0.14 | 44 | 0.88 ± 0.15 | ||
| Change from baseline | 43 | -0.03 ± 0.09 | 44 | -0.04 ± 0.09 | 0.9399 a | |
| p-value c | 0.0204 | 0.0133 | ||||
| BUN (mg/dl) | Baseline (Visit 2) | 53 | 13.19 ± 3.49 | 51 | 12.50 ± 3.31 | 0.2982 a |
| 12w (Visit 4) | 43 | 13.29 ± 2.74 | 44 | 12.48 ± 3.63 | ||
| Change from baseline | 43 | -0.21 ± 3.88 | 44 | 0.01 ± 3.62 | 0.7800 a | |
| p-value c | 0.7223 | 0.9802 | ||||
| Uric acid (mg/dl) | Baseline (Visit 2) | 53 | 6.12 ± 1.42 | 51 | 6.37 ± 1.45 | 0.3804 a |
| 12w (Visit 4) | 43 | 6.31 ± 1.64 | 44 | 6.25 ± 1.51 | ||
| Change from baseline | 43 | -0.04 ± 0.96 | 44 | -0.10 ± 0.71 | 1.0000 b | |
| p-value | 0.6192 d | 0.3534 c | ||||
a
Compared between groups; p-value for Two sample t-test.
b
Compared between groups; p-value for Wilcoxon rank sum test.
c
Compared within groups; p-value for Paired t-test.
d
Compared within groups; p-value for Wilcoxon signed rank test.